Guangchuang Yu

School of Public Health, The University of Hong Kong (852)-62269693
L5-14, 5/F, Laboratory Block, Faculty of Medicine Building
22 Sassoon Road, Pokfulam, Hong Kong


PhD; The University of Hong Kong; Evolution Study of Influenza A Virus
MSc; Anhui Medical University; Biochemistry and Molecular Biology
BSc; South China Agricultural University; Biotechnology
Institut Pasteur, Paris; Train the Trainers 2015

Professional Experience

Research Assistant I; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong
Member; International Society for Influenza and other Respiratory Virus Diseases
INDA Steering Committee; International Network for Data Analysis, Institut Pasteur
Bioinformatician; College of Life Science and Technology, Jinan University
Visiting Student; Beijing Institute of Radiation Medicine

Teaching Experience

Student Helper; BIOL6001 Presentation Skills and Research Seminars in Biological Sciences (postgraduate course), The University of Hong Kong
Lecturer; Functional Proteomics (postgraduate course), Jinan University


Postgraduate Studentships (for PhD students at The University of Hong Kong)
Best paper of the year 2010, Journal of Integrated OMICS.


(completed) PI, Investigate functions of hnRNPK in regulating cytokinesis of human lung cancer cell, Fundamental Research Funds for the Central Universities (21613414), ¥100,000
(completed) PI, Dynamic proteomic analysis of HeLa cell cycle, Fundamental Research Funds for the Central Universities (21611303), ¥20,000

Professional Services

Associate Editor
Journal of Integrated OMICS, 2011-


BMC Bioinformatics

Computational Biology and Chemistry

Current Bioinformatics

Gastroenterology Research and Practice

Molecular BioSystems

R Journal


Native language
Chinese Mandarin
Very fluent
Very fluent

Programming Skills




Software Development

Badge for R Package
Download Stats of R Packages
Emoji and Font Awesome in Graphics
Use Image in ‘ggplot2’
Create Meme
R/Package Version Check
Scatter Pie Plot
Shadow Text Grob and Layer

ChIPseeker for ChIP peak Annotation, Comparison, and Visualization
statistical analysis and visualization of functional profiles for genes and gene clusters
Disease Ontology Semantic and Enrichment analysis
an R package for visualization and annotation of phylogenetic trees with their covariates and other associated data
GO-terms Semantic Similarity Measures
MeSH Enrichment and Semantic analyses
Reactome Pathway Analysis
Visualization Tool for Sequence Recombination and Reassortment
Base Classes and Functions for Phylogenetic Tree Input and Output

Taxa Insertion by Parsimony

Contributions to open source libraries

Messages, Warnings, Strings with Ascii Animals
Base Functions and Classes for Mass Spectrometry and Proteomics

Research Highlights

Citation = 1133, H-index = 14, I10-index = 17

(data from Google Scholar, Nov 2017)

Ontology Semantic Similarity Analysis

Pathway Analysis

Genomic Analysis

Proteomic Analysis

Evolutionary Analysis


  1. G Yu, DK Smith, H Zhu, Y Guan, TTY Lam*. ggtree: an R package for visualization and annotation of phylogenetic trees with their covariates and other associated data. Methods in Ecology and Evolution. 2017, 8(1):28-36. Altmetric
  2. G Yu, QY He*. ReactomePA: an R/Bioconductor package for reactome pathway analysis and visualization. Molecular BioSystems. 2016, 12(2):477-479.
  3. G Yu*, LG Wang, QY He*. ChIPseeker: an R/Bioconductor package for ChIP peak annotation, comparision and visualization. Bioinformatics. 2015, 31(14):2382-2383.
  4. G Yu*, LG Wang, GR Yan, QY He*. DOSE: an R/Bioconductor package for Disease Ontology Semantic and Enrichment analysis. Bioinformatics. 2015, 31(4):608-609.
  5. G Yu, LG Wang, XH Meng, QY He*. LXtoo: an integrated live Linux distribution for the bioinformatics community. BMC Research Notes. 2012, 5(1):360.
  6. G Yu, LG Wang, Y Han, QY He*. clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS: A Journal of Integrative Biology. 2012, 16(5):284-287. citation
  7. G Yu, QY He*. Functional similarity analysis of human virus-encoded miRNAs. Journal of Clinical Bioinformatics. 2011, 1(1):15.
  8. G Yu, CL Xiao, X Bo, CH Lu, Y Qin, S Zhan, QY He*. A new method for measuring functional similarity of microRNAs. Journal of Integrated OMICS. 2011, 1(1):49-54.
  9. G Yu, CL Xiao, CH Lu, HT Jia, F Ge, W Wang, XF Yin, HL Jia, JX He*, QY He*. Phosphoproteome profile of human lung cancer cell line A549. Molecular BioSystems. 2011, 7(2):472-479.
  10. G Yu, F Li, Y Qin, X Bo*, Y Wu, S Wang*. GOSemSim: an R package for measuring semantic similarity among GO terms and gene products. Bioinformatics. 2010, 26(7):976-978. citation
  11. X Sun, G Yu, Q Xu, N Li, C Xiao, X Yin, K Cao, J Han, QY He*. Putative cobalt- and nickel-binding proteins and motifs in Streptococcus pneumonia. Metallomics. 2013, 5(7):928-935.
  12. YY Zhu, G Yu, Y Zhang, Z Xu, YQ Huang, GR Yan*, QY He*. A novel andrographolide derivative AL-1 exerts its cytotoxicity on K562 cells through a ROS-dependent mechanism. Proteomics, 2013, 13(1):169-178.
  13. XY Yang, K He, G Du, X Wu, G Yu, Y Pan, G Zhang*, X Sun*, QY He*. Integrated Translatomics with Proteomics to Identify Novel Iron–Transporting Proteins in Streptococcus pneumoniae. Frontiers in Microbiology. 2016, 7:78.
  14. PY Huang, CCD Lee, CH Yip, CL Cheung, G Yu, TTY Lam, DK Smith, H Zhu*, Y Guan*. Genetic characterization of highly pathogenic H5 influenza viruses from poultry in Taiwan, 2015. Infection, Genetics and Evolution. 2016, 38:96-100.
  15. SH Xu, JZ Huang, ML Xu, G Yu, XF Yin, D Chen*, GR Yan*. ACK1 Promotes Gastric Cancer Epithelial-Mesenchymal Transition and Metastasis through AKT-POU2F1-ECD Signaling. The Journal of Pathology. 2015, 236(2):175-185.
  16. Z Guo, J Han, XY Yang, K Cao, K He, G Du, G Zeng, L Zhang, G Yu, Z Sun, QY He*, X Sun*. Proteomic analysis on the copper resistance of Streptococcus pneumonia. Metallomics. 2015, 7(3):448-454.
  17. XY Yang, L Zhang, J Liu, N Li, G Yu, K Cao, J Han, G Zeng, Y Pan, X Sun*, QY He*. Proteomic analysis on the antibacterial activity of a Ru(II) complex against Strepococcus pneumonia. Journal of Proteomics. 2015, 115:107-116.
  18. N Wang, J Zhang, L Zhang, XY Yang, N Li, G Yu, J Han, K Cao, Z Guo, X Sun*, QY He*. Proteomic analysis of putative heme-binding proteins in Streptococcus pyogenes. Metallomics. 2014, 6(8):1451-1459.
  19. H Sun*, J Weng, G Yu, RH Massawe. A DNA-Based Semantic Fusion Model for Remote Sensing Data. PLoS One. 2013, 8(10):e77090.
  20. GR Yan, Z Tan, Y Wang, ML Xu, G Yu, Y Li*, QY He*. Quantitative Proteomics Characterization on the Anti-tumor Effects of Isodexyelephantopin against Nasopharyngeal Carcinoma. Proteomics. 2013, 13(21):3222-3232.
  21. J Li, X Lu, Q Wu, G Yu, Z Xu, L Qiu, Z Pei, Y Lin, J Pang*. Design, SAR, angiogenic activities evaluation and pro-angiogenic mechanism of new marine cyclopeptide analogs. Current Medicinal Chemistry. 2013, 20(9):1183-1194.
  22. Y Han, G Yu, H Sarioglu, A Caballero-Martinez, F Schlott, M Ueffing, H Haase, C Peschel, AM Krackhardt*. Proteomic investigation of the interactome of FMNL1 in hematopoietic cells unveils a role in calcium-dependent membrane plasticity. Journal of Proteomics. 2013, 78:72-82.
  23. Y Ma, J Yang, X Fan, H Zhao, W Hu, Z Li, G Yu, X Ding, J Wang, X Bo, X Zheng, Z Zhou*, S Wang*. Cellular MicroRNA let-7c Inhibits M1 Protein Expression of the H1N1 Influenza A Virus in Infected Human Lung Epithelial Cells. Journal of Cellular and Molecular Medicine. 2012, 16(10):2539-2546.
  24. GR Yan, FY Zhou, BL Dang, Y Zhang, G Yu, X Liu, QY He*. Genistein-induced mitotic arrest of gastric cancer cells by downregulating KIF20A, a proteomics study. Proteomics. 2012, 12(14):2391-2399.
  25. X Sun, XY Yang, XF Yin, G Yu, CL Xiao, X He, QY He*. Proteomic Analysis of Membrane Proteins from Streptococcus pneumoniae with Multiple Separation Methods plus High Accuracy Mass Spectrometry. OMICS: A Journal of Integrative Biology. 2011, 15(10):683-694.

Book Chapters

  1. G Yu, “Bioinformatics II”, in “Functional Protein Research”, 385-425, Qing-Yu He (Eds), Science Press, 2012. (China’s Twelfth Five-Year National Important Books Project, in Chinese)

Conference Presentations

  1. ggtree for tree visualization & annotation (invited), Phylogenetic tree visualization workshop/hackathon, The Field Museum of Natural History, Chicago, May. 2017
  2. Computational Methods in Ecology and Evolution, The Second International Workshop on Environmental Microbiomes, Sun Yat-sen University, Guangzhou, April. 2017
  3. ggtree for visualization and annotation of phylogenetic trees (invited), The 9th China-R Conference, Renmin University of China, Beijing, May. 2016

Conference Posters

  1. ggtree: a programming package for complex data integration and analysis in phylogeny to identify potential genetic markers of influenza a virus that determine interspecies transmission, Scientific Advisory Board (SAB) Meeting for the Theme-based Research Scheme on Viral, Host and Environmental Determinants of Influenza Virus Transmission and Pathogenesis, The University of Hong Kong, Hong Kong, Jun. 2017
  2. Phylogeny-guided genome assembly method for short read nucleotide sequences from co-infecting influenza A viruses, Options IX for the control of influenza, International Society for Influenza and other Respiratory Virus Disease, Chicago, Aug. 2016
  3. ggtree: an R package for visualization and annotation of phylogenetic tree with different types of meta-data, The 20th Research Postgraduate Symposium, The University of Hong Kong, Hong Kong, Dec. 2015