GOSemSim: GO semantic similarity measurement

The semantic comparisons of Gene Ontology (GO) annotations provide quantitative ways to compute similarities between genes and gene groups, and have became important basis for many bioinformatics analysis approaches. GOSemSim is an R package for semantic similarity computation among GO terms, sets of GO terms, gene products and gene clusters. GOSemSim implemented five methods proposed by Resnik, Schlicker, Jiang, Lin and Wang respectively.

GOSemSim is released within the Bioconductor project and the source code is hosted on GitHub.


Guangchuang Yu, School of Public Health, The University of Hong Kong.


Please cite the following article when using GOSemSim:


Yu G, Li F, Qin Y, Bo X*, Wu Y and Wang S*. GOSemSim: an R package for measuring semantic similarity among GO terms and gene products. Bioinformatics. 2010, 26(7):976-978.

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Install GOSemSim is easy, follow the guide in the Bioconductor page:

## try http:// if https:// URLs are not supported
## biocLite("BiocUpgrade") ## you may need this



Combine methods for aggregating multiple GO terms


Supported organisms

Find out details and examples on Documentation.

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Projects that depend on GOSemSim

CRAN packages

Bioconductor packages