To my knowledge, BioEdit is the most comprehensive biological sequence alignment editor. Most of my labmates run this software using
Parallels Desktop. For some of them, BioEdit is the only reason to install
I need to edit my alignment recently, and install it in my iMac using Wine, which is a compatibility layer for running Windows applications on POSIX-compliant OS. Although it is famous in Linux community for many years, many OSX users never heard of it.
更新EI Capitan已经近一个月，第一感觉就是明显变慢了。这是去年买的27’ iMac，必须不慢。 MS office程序可以打开，但打开文档直接闪退。升级安装总会有些问题，就像我去年在笔记本上升级yosemite一样，最后两分钟始终过不去，迫使我全新安装，当时我看后台记录就发现了是MacTex拷不过去， 后来MacTex的网站上也写了升级Yosemite有这个问题。升级有些小问题是可以预见的，但很少有像EI Capitan这么多的问题。
Macworld EI Capitan review文章中有人这样评论：
haha nice review ! did you tried the update ?? slow connection safari freezes on launch outlook crash printer does not work anymore great job from Apple . My confidence in Apple has been seriously dented!
Installing OS is painful, you need to re-install all the software and configure them to the way you want. We don’t want to wast time in doing this. To prevent doing this dirty job, we perform an upgrade install instead of clean install. We all have experience of upgrading Windows sucks, same as OS X. All the issues you have in old system will be remained, and sometimes new issues will be introduced in the process of upgrading. The system will be slower compare to clean install one.