Abstract
SUMMARY: The semantic comparisons of Gene Ontology (GO) annotations
provide quantitative ways to compute similarities between genes and gene
groups, and have became important basis for many bioinformatics analysis
approaches. GOSemSim is an R package for semantic similarity computation
among GO terms, sets of GO terms, gene products and gene clusters. Four
information content (IC)- and a graph-based methods are implemented in
the GOSemSim package, multiple species including human, rat, mouse, fly
and yeast are also supported. The functions provided by the GOSemSim
offer flexibility for applications, and can be easily integrated into
high-throughput analysis pipelines. AVAILABILITY: GOSemSim is released
under the GNU General Public License within Bioconductor project, and
freely available at
http://bioconductor.org/packages/2.6/bioc/html/GOSemSim.html.
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